Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings

trajkovski / / Publications

Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder. Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.

Keywords: autistic disorder,diet,family

Stress that parents of autistic children and parents of children with cerebral palsy face with

trajkovski / / Publications

Natasha Mateska1, Vladimir Trajkovski2

1unemployed special educator

2University “Ss. Cyril and Methodius”, Faculty of Philosophy, Institute of Special Education and Rehabilitation, Skopje, Republic of Macedonia

Introduction: Autism is a diagnose that affects every member of the family in different ways. Parents should focus a bigger part of their attention toward the autistic child, which can cause a stressful effect in the family as well as outside the family.

Aim of the study: To determine the stress that parents of autistic children face with compared to parents of children with cerebral palsy.

Methodology: The entire sample includes 90 respondents, of which 45 parents of autistic children and the rest 45 parents of children with cerebral palsy. The survey was conveyed using a questionnaire and methods of descriptive and comparative analysis were used. The comparison of the groups of surveyed was analyzed by using χ2 test and Fisher Exact test. The differences that were taken into consideration were on the level of significance p<0.05.

Results: Parents of autistic children compared with parents of children with cerebral palsy, statistically show significant difference for following variables: support from close community (χ2=7.57, df=1, p=0.006), stigmatization by family and community (χ2=5.4, df=1, p=0.02), isolation by the community (χ2=10.3, df=1, p=0.001), change in the relationship between spouses (χ2=7.53, df=1, p=0.006).

Conclusion: The parents of autistic children are faced with bigger stress in managing the everyday activities and control of life, compared with parents of children with cerebral palsy.

Key words: stress, parents, autism, cerebral palsy

Citation: Mateska N, Trajkovski V. Stress that parents of autistic children and parents of children with cerebral palsy face. Book of abstracts ‡ 9th International Scintific Conference – „Special Education and Rehabilitation Today“. Belgrade, September 25-27, 2015; 31.

Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: retrospective study.

trajkovski / / Publications
Croatian Medical Journal [01 Dec 2004, 45(6):746-749]
Type: Research Support, Non-U.S. Gov’t, Journal Article

Abstract

AIM: To examine plasma concentration of IgA, IgM, IgG classes, and IgG1, IgG2, IgG3, and IgG4 subclasses in children with autism. METHODS: Infantile autism was diagnosed by the Diagnostic and Statistical Manual for Mental Disorders (DSM)-IV and the International Classification of Diseases (ICD)-10 criteria. Plasma samples were collected from 35 autistic subjects, and their 21 siblings (biological brothers and sisters) who served as healthy controls. Plasma samples were separated by centrifugation and stored at -20 degrees C until the determination. Plasma immunoglobulin classes (IgM, IgA, IgG) and subclasses (IgG1, IgG2, IgG3, IgG4) were determined using a nephelometer. RESULTS: Plasma concentrations (mean+/-standard deviation) of IgM and IgG in autistic children (1.36+/-0.31 g/L and 13.14+/-1.27 g/L, respectively) were significantly higher (p=0.031 and p=0.023, respectively) in comparison with their healthy brothers or sisters (1.20+/-0.15 g/L and 12.39+/-0.96 g/L, respectively). Children with autism had significantly higher plasma concentrations of IgG4 (p<0.001) compared to their siblings (healthy brothers or sisters). Plasma concentration of IgA, IgG1, IgG2, and IgG3 were similar in autistic children and their healthy brothers or sisters. Increased plasma concentration of IgG1 was found (p=0.027) in autistic males (8.06+/-2.40), as compared with their healthy brothers (5.24+/-4.13 g/L). Plasma concentrations of IgG (14.28+/-3.66 g/L), and IgG1 (9.41+/-2.20 g/L) in autistic females were increased (p=0.012 and p=0.021, respectively) in comparison with IgG (11.07+/-2.07) and IgG1 (6.37+/-3.38 g/L) in their healthy sisters. CONCLUSION: Children with autism have increased plasma concentration of immunoglobulines. Increased immunoglobulines in children with autism could be a result of impaired development of the immune system, and/or genetic factors connected with defense mechanism in these children.

ORCIDs linked to this article

Source: https://europepmc.org

A multimodal intervention for children and adults with autism spectrum disorders: ‘ReAttach’

trajkovski / / Conferences

Paula Weerkamp-Bartholomeus, Ph.D.1, Prof. Dr. Vladimir Trajkovski2

1ReAttach Therapy Institute, Eindhoven, The Netherlands, e-mail: info@reattach-therapy-institute.com

2Institute of Special Education and Rehabilitation, Faculty of Philosophy, University “Ss. Cyril and Methodius” Blvd. Goce Delchev 9A, 1000 Skopje, Republic of Macedonia, e-mail vladotra@fzf.ukim.edu.mk

 Abstract

Introduction: Autism spectrum disorders (ASD) are characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors, which has considerable impact on daily life functioning. ReAttach is an intervention based on attachment, arousal regulation and training multiple sensory integration processing.

Aim: investigate the effectivity of ReAttach in terms of improvement of daily life functioning.

Method: Eight therapists were trained to perform ReAttach with a group of participants (N=58). Comparison of the mean scores on the Autism Treatment Evaluation Checklist (ATEC) was conducted with a paired sample t-test.

Results: In this study we have explored the potential of 5 sessions of ReAttach to significantly improve the ATEC scores of participants diagnosed with ASD within a short period of time. The results revealed significant decreases of problems (p<0.001) in the subscales: I. Speech (t=9.96, df=57, p=0.000), II. Sociability (t=13.72, df=57, p=0.000), III. Sensory Cognitive Awareness (t=11.91, df=57, p=0.000), IV. Health / Physical / Behavior (t=11.64, df=57, p=0.000) and total scores of the ATEC (t=15.23, df=57, p=0.000).

We made comparison of mean total scores in various diagnosis within the whole ASD group: Autistic disorder (N=6, age M=18.67, SD±6.92, males were 100%) t=4.78, df=5, p=0.005; Asperger syndrome (N=24, age M=27.75, SD±12.88 males were 70.83%)  t=10.56, df=23, p=0.000; PDD-NOS (N=24, age  M=22.17, SD±11.68, males were 83.33%), t=9.26, df=23, p=0.000; ASD and Intellectual Disability (N=4, age M=26.75, SD±16.17, males were 75%) t=4.40, df=3, p=0.022.

Conclusions: This study confirms that ReAttach has a positive impact on daily life functioning. Practical research confirms the hypothesis that this intervention has a positive effect on various developmental areas described in the ATEC. The results further suggest that people within the entire range of ASD can benefit from ReAttach and the method itself might provide important clues to efficient ASD treatment.

Keywords: autism, innovation, treatment

Citation: Weerkamp Bartholomeus P, Trajkovski V. Multimodalna intervencija za decu i odrasle sa autističnim spektrom poremećaja: „Reattach“. Zbornik rezimea ‡ IV stručno-naučni skup sa međunarodnim učešćem „Aktuelnosti u edukaciji i rehabilitaciji osoba sa smetnjama u razvoju“. Beograd, 24-25 oktobar, 2015; 19.

#AUTISM PCP – A hollistic approach of person-centred planning for people with Autism

trajkovski / / Projects

AUTISM PCP‘ is an innovative cross-sectoral partnership project with strong European

added value; as such, ‘AUTISM PCP’ addresses important horizontal as well as sectoral priorities

for the European Union, such as ‘social inclusion, adult learning policies and Early School

Leaving (ESL).

The main objectives of  ‘AUTISM_PCP’ are:

– Empowerment of individuals at risk of social exclusion and more specifically empowerment of ASC

individuals

– Strengthening of the overall effort for social inclusion and integration of ASC individuals at

mainstream education & society at large

– Enhancing competences of professionals and all those individuals, such as family members & relatives, etc., involved in the life of ASC individuals

– Raise awareness  to the general public with regards to social inclusion of pupils with Autism

Source: http://www.autismholistic.eu/

WHAT CAN REATTACH DO FOR INDIVIDUALS WITH AUTISM?

trajkovski / / ReAttach Therapy Foundation

Let’s take a few minutes to explain the impact of the multimodal approach of ReAttach:

  • ReAttach trains Multiple Sensory Integration Processing
  • ReAttach trains coherent concepts
  • ReAttach trains complex social cognitive skills and we start at a very low entry level
  • Our therapists use cognitive bias modification to practise new neuropsychological patterns and new thinking strategies that might be very useful in situations that are quite complicated

 

This results in:

  • The ability to learn from new experiences (problems with transfer disappear)
  • The ability to understand social concepts and read the non-verbal cues and social rules and behaviours that are not explicitly explained
  • Self-awareness and behaviour control
  • Improvement of executive functioning
  • Sensory overload decreases or disappears because sensory information can be processed quicker and better in a coherent way (by multiple sensory integration processing)
  • The development of new skills such as: imagination, expressing emotions, showing empathy, theory of mind, mentalization, reading your own body signals

 

With pre-verbal children or adults with autism ReAttach can achieve this:

  • Multiple Sensory Integration Processing
  • Coherent concepts of the self and others
  • Differentiation between the self and others
  • Echolalia changes into communication addressing to the self and the other
  • Exploration and play.

In the Netherlands we already provide the ReAttach for Autism intervention in institutions for Mental Health, private practises and institutions for people with cognitive disabilities. In WTA March 2015 a case study was published in Dutch.

The method has been presented at the World Autism Organisation Conference in 2014 and 2016 and at the Autism Challenges and Solutions Conference in Moscow, April 2016.

The practical research has been published in Clinical Neuropsychiatry, a peer-reviewed journal for treatment evaluation. It has been rewarded with a nomination of the Clinical Neuropsychiatry Award.http://clinicalneuropsychiatry.org

Prof Dr Vladimir Trajkovski has presented this autism research paper in Belgrade last year and represents us in the Balkan region.

In Prof Dr Michael Fitzgerald’s book Autism Recent Advances there is a chapter on ReAttach about a case study with a patient with Asperger syndrome. http://www.intechopen.com/books/autism-spectrum-disorder-recent-advances/reattach-the-exciting-development-of-a-promising-intervention-for-autism-spectrum-disorders

Availability

International training courses are scheduled to deliver the ReAttach for Autism in the upcoming year to: Belgium (Gent, Leuven, Antwerpen), Singapore, United Kingdom (London), Germany (Keulen, Mannheim, Muenster), Italy (Rome), Vancouver BC, Australia (Sydney, Melbourne,) and New York.

For more information you may contact ReAttach Therapy Institute
info@reattach-therapy-institute.com

Source: AutsimEye

FAMILY ANALYSIS OF IMMUNOGLOBULIN CLASSES AND SUBCLASSES IN CHILDREN WITH AUTISTIC DISORDER

trajkovski / / Uncategorized
. 2009 Nov; 9(4): 283–289.
PMCID: PMC5603683
PMID: 20001993

Abstract

Autistic disorder is a severe neurodevelopment disorder characterized by a triad of impairments in reciprocal social interaction, verbal and nonverbal communication, and a pattern of repetitive stereotyped activities, behaviours and interests. There are strong lines of evidence to suggest that the immune system plays an important role in the pathogenesis of autistic disorder. The aim of this study was to analyze quantitative plasma concentration of immunoglobulin classes, and subclasses in autistic patients and their families. The investigation was performed retrospectively in 50 persons with autistic disorder in the Republic of Macedonia. Infantile autistic disorder was diagnosed by DSM-IV and ICD-10 criteria. Plasma immunoglobulin classes (IgM, IgA, and IgG) and subclasses (IgG1, IgG2, IgG3, and IgG4) were determined using Nephelometer Analyzer BN-100. Multiple comparisons for the IgA variable have shown statistically significant differences between three pairs: male autistic from the fathers (p = 0,001), female autistic from the mothers (p = 0,008), as well as healthy sisters from the fathers (p = 0,011). Statistically significant differences found between three groups regarding autistic disorder (person with autistic disorder, father/mother of a person with autistic disorder, and brother/sister) independent of sex belongs to IgA, IgG2, and IgG3 variables. Multiple comparisons for the IgA variable have shown statistically significant differences between children with autistic disorder from the fathers and mothers (p < 0,001), and healthy brothers and sisters from the fathers and mothers (p < 0,001). Comparison between healthy children and children with autistic disorder from the same family should be tested for immunoglobulin classes and subclasses in order to avoid differences between generations.

Keywords: autistic disorder, immunoglobulin classes, immunoglobulin subclasses, family analysis
Source: PMC

IMPACT of Parent Education on Families in South-EAST Europe

trajkovski / / Conferences
Saturday, May 12, 2018: 11:30 AM-1:30 PM
Hall Grote Zaal (de Doelen ICC Rotterdam)
D. R. Preece1, J. Stošić2, E. Theodorou3, J. Troshanska4, K. Mavrou3, L. Symeou3, J. Frey Škrinjar2 and V. Trajkovski5, (1) Faculty of Education and Humanities, University of Northampton, Northampton , United Kingdom of Great Britain and Northern Ireland, (2) Department of Inclusive Education and Rehabilitation, University of Zagreb, Zagreb, Croatia, (3) School of Humanities, Social and Education Sciences, European University Cyprus, Nicosia, Cyprus, (4) Macedonian Scientific Society for Autism, Skopje, Macedonia, The former Yugoslav Republic of, (5)Faculty of Philosophy, University of Ss Cyril and Methodius, Skopje, Macedonia, The former Yugoslav Republic of
Background: Autism challenges traditional parenting styles, and can make parents feel deskilled and disempowered, especially if little information or support is available to them. Providing accurate information about autism to parents, and teaching them to adapt their parenting using good autism practice has been shown to be effective in improving personal, educational and social outcomes for individuals with autism and their families (Bearss et al 2015, Farmer and Reupert 2013). However, such support is extremely limited or non-existent within some south-east European countries.

Objectives: A three-year European Union-funded project has been established involving family members, professionals and academics. Its objectives are to develop a core parent autism education curriculum and locally appropriate parent education materials and methods; to provide parent education in three diverse south-eastern European countries (Croatia, Cyprus and the Former Yugoslav Republic of Macedonia) where diagnosis and service provision are emergent; to develop local parent education teams within these countries to ensure sustainability; and to evaluate the impact of the parent education events upon families attending.

Methods: After reviewing the literature and surveying parental priorities in the three countries, a 12-hour parent education programme and locally differentiated training materials were developed. In total, five cohorts of approximately 20 parents each will receive parent education within each of the three countries. A combined process and outcome mixed methods evaluation methodology (Royse et al 2009) is being used to evaluate the project. Data are gathered via pre-attendance, post-attendance and follow-up (3-month) parent questionnaires – incorporating the CarerQoL quality of life scale (Hoefman et al 2014) – from all participants, semi-structured interviews with a purposive sample of parents, trainer focus groups and reflective diaries, and document analysis. We here report on quantitative (n = 108) and qualitative data (n = 20) from parent cohorts 1 and 2.

Results: Quantitative data identify that >90% of respondents have improved their understanding of autism, >80% report improved child communication and >75% report improvements in overall family life, their ability to predict their child’s behaviour and their ability to respond to concerns and comments from the broader family. Carer QoL data indicate increased parental happiness following attendance (p=.001). Key themes from qualitative data are the positive impact of attending the parent education programme, increased awareness regarding sensory and communication issues and improvements in everyday life. Parents also reported that attendance provided opportunities to meet other parents and reduced social isolation.

Conclusions: Data from parent cohorts 1 and 2 identify that parents who have attended the parent education programme have found it beneficial, and that it has had a positive impact on their family life. Key areas of impact have been improvements in communication and improved management of sensory and behavioural issues. This supports the continued and wider provision of parent education within these countries. Further data from cohorts 3 and 4 will have been collected and analysed by the time of INSAR 2018.

Source: INSAR

MSSA in OMICS International

trajkovski / / General

Macedonian Scientific Society for Autism is a general public of residents unique teachers, specialists, restorative specialists, immunologists, allergologists, and other expert and experimental controls, built up by a through and through freedom of the subjects to achieve and facilitate their interests and to perform exercises and activities went for enhancing examination and treatment of the people with a mental imbalance in the Republic of Macedonia. Macedonian Scientific Society for Autism is managing more extensive normal premium, and the Society’s unique points and the assignments: examination components associated with a mental imbalance; examination the impacts of recovery on the people with extreme introvertedness; • treatment of the people with a mental imbalance; collaboration with the guardians of the kids with a mental imbalance; coordination of legislative and non-administrative associations managing a mental imbalance.

Source: OMICS International

ASSOCIATION BETWEEN CEREBRAL PALSY AND AUTISM SPECTRUM DISORDERS

trajkovski / / Conferences

VLADIMIR TRAJKOVSKI, MD, PhD, Full Professor

Macedonian Scientific Society for Autism, Institute of Special Education and Rehabilitation, Faculty of Philosophy, University “Ss. Cyril and Methodius”

Address: Blvd. “Goce Delchev 9A, 1000 Skopje, Republic of Macedonia

E-mail: vladotra@fzf.ukim.edu.mk

Abstract

Relevance: Clinical heterogeneity among children with neurodevelopmental disorders reflects diversity in strengths and needs that can have important implications for therapeutic management. Autism Spectrum Disorder (ASD) is sometimes a co-occurring associated condition of cerebral palsy. Whereas cerebral palsy affects motor functioning, autism affects certain areas of brain development. Cerebral palsy (CP) is primarily a motor disorder, caused by a cerebral lesion occurring in the developing brain.

Purpose: To explore autism spectrum symptoms in children with cerebral palsy (CP), and the association between autism spectrum symptoms and medical and psychiatric co-morbidity.

Results: Over the past two decades there has been greater recognition that risk of mental health and neurobehavioral disorders is shared across the broad continuum of developmental medicine, including cerebral palsy. The current best practice for diagnosing ASD in a child with CP is completing a thorough clinical assessment and combining this with the clinician’s

judgement. The assessment of ASD in the face of CP should entail a detailed history, examination and structured observation of the child’s social and communication skills, complemented with standardized diagnostic instruments which are validated for children with motor difficulties. Both conditions are discovered at roughly the same age, usually. Cerebral palsy is usually discovered a little earlier, at perhaps 6 months to 2 years of age. Autism is discovered a little later, usually by 5 years of age.  They are highly variable, with some symptoms present in some children but not others. Both conditions can be very severe or hardly noticeable.

Conclusions: A holistic approach is required when evaluating a child who demonstrates impairments in social communication skills in the presence of motor impairment More attention should be given to autism spectrum symptoms in the regular follow-up of children with CP in an attempt to enhance social functioning.

Key words: cerebral palsy, autism spectrum disorders, neurodevelopmental disorders.